We have used resonant acoustic mixing to study three reactions in organic chemistry and prepare APIs at the multigram scale. The results, published in ChemSusChem, outperformed traditional-solvent based chemistry.
Solvents are well-known pollutants that pose significant waste management and health concerns. Such pollution problems have led to increasing restrictions on solvent use, as reflected by the recent US legislation on dichloromethane, published in May 2024. In this context, mechanochemistry could reshape the industry, supplying the world with pharmaceutical products while avoiding the use of toxic solvents.
There are as many solvents as there are uses for them: from cosmetics to the textile industry, through pharmaceutical manufacturing to oil production. The history of chemistry is, in part, a chronicle of the discovery and development of these substances over time, until now: their application is increasingly restricted, which has led to the emergence of greener alternatives, such as mechanochemistry.
We’re launching our IMPACTIVE webinar series to discuss mechanochemistry, green pharmaceuticals, and green chemistry. Save the date: our first session will take place on 28 May at 12:00 pm (noon) CEST, with a presentation by Evelina Colacino, our project coordinator.
Emmanuel Mignot visited the Institut Charles Gerhardt Montpellier (ICGM) at the University of Montpellier, France, to discover more about IMPACTIVE. It was an exceptional opportunity to exchange ideas and strengthen relations with our Estonian partners.
Welcome to the second edition of our helpful glossary, which explains key terms and concepts in the fascinating world of mechanochemistry. Enjoy!
This pioneering study, using a drum mill for the first time for co-crystal formation, opens new pathways for sustainable, large-scale pharmaceutical co-crystal production
We are launching a helpful glossary that explains key terms and concepts in the fascinating world of mechanochemistry. This is the first of our four editions. Enjoy!
The IMPACTIVE project is launching a spin-off company. We’re looking for a visionary CEO to lead the way and shape the future of sustainable API manufacturing.
Our researchers from Radboud University are at the core of IMPACTIVE. This team works on exploring new reactions to synthesise pharmacologically active compounds at a lab scale while avoiding the use of solvents.