The IMPACTIVE team has looked into the manufacturing of imatinib: an anticancer drug on the Essential Medicines’ list of the Worlds’ Health Organisation. Thanks to mechanochemistry, we discovered a synthetic route to do it in a way that is safer, greener and more efficient than the commercial method used nowadays.
Mechanochemistry is a groundbreaking field, revolutionizing chemistry through force-triggered reactions, eco-friendly practices, and efficient processes. It’s a pioneer technology with applications across multiple fields: biomass transformation, energy storage, agrochemicals, and much more. With its versatility and sustainability, it’s reshaping a myriad of industries towards a greener, more innovative future. Keep reading to unveil different use-cases.
We turn one year old, and we celebrate it by publishing our Annual Report, that analyses our latest developments.
Last week, chemists from around the world gathered at the IUPAC Conference in The Hague, Netherlands. IMPACTIVE researchers had a strong presence throughout the conference, with a dedicated focus session on mechanochemistry, as well as oral and poster presentations highlighting the first results of the project.
Have you ever thought about the environmental impact of the pills we take? We have, and we want to do something about it. From the different techniques we use, to the environmental analyses we perform, this article unravels all you need to know about IMPACTIVE.
Grinding stuff sounds simple. In fact, it’s oddly one of the oldest ways to carry out chemical reactions. And, although solvent-based chemistry still dominates the industry, mechanochemistry –transformations enabled by mechanical force– experiences a new surge, an exciting era of rediscovery. Inspired by the 12 principles of green chemistry, mechanochemistry could really reshape chemical and pharmaceutical manufacturing. Read on to discover how mechanochemistry could catalyse cleaner and greener synthetic solutions.
IMPACTIVE is a project funded by Horizon Europe to study the possibilities of mechanochemistry in the synthesis of active pharmaceutical ingredients. This initiative counts on 17 partners in academia and industry, which will work together towards green production processes to increase sustainability and reinforce the European supply chain.
