Grinding stuff sounds simple. In fact, it’s oddly one of the oldest ways to carry out chemical reactions. And, although solvent-based chemistry still dominates the industry, mechanochemistry –transformations enabled by mechanical force– experiences a new surge, an exciting era of rediscovery. Inspired by the 12 principles of green chemistry, mechanochemistry could really reshape chemical and pharmaceutical manufacturing. Read on to discover how mechanochemistry could catalyse cleaner and greener synthetic solutions.