Our researchers at Trinity College Dublin, in Ireland, master the spray drying technique. This team is exploring how to apply such method to achieve greener pharmaceuticals with a strong focus on industrial production.
We have used resonant acoustic mixing to study three reactions in organic chemistry and prepare APIs at the multigram scale. The results, published in ChemSusChem, outperformed traditional-solvent based chemistry.
Our researchers from Radboud University are at the core of IMPACTIVE. This team works on exploring new reactions to synthesise pharmacologically active compounds at a lab scale while avoiding the use of solvents.
Our Belgian partners are experts in creating highly interesting enantiopure compounds through a chemical process known as deracemisation. If you want to know more details, keep reading.
Our project leader, the University of Montpellier, wears many hats. They ensure smooth collaboration among partners while leading the development of innovative mechanochemical methods at lab scale.
The IMPACTIVE team has investigated the manufacturing of the popular drug paracetamol using mechanochemistry. For the first time we accomplished the use of bead-milling technology for the solvent-free synthesis of the medicine, outperforming traditional solution-based methods.
The IMPACTIVE team has looked into the manufacturing of imatinib: an anticancer drug on the Essential Medicines’ list of the Worlds’ Health Organisation. Thanks to mechanochemistry, we discovered a synthetic route to do it in a way that is safer, greener and more efficient than the commercial method used nowadays.
IMPACTIVE is a very ambitious project, with members of the greatest background diversity. Altogether, we want to get rid of the solvents in the current pharmaceutical processes and substitute them with mechanochemistry, a greener, more sustainable approach.